Differential metapathway sensitivity:

Metapathway info:

Select a row to explore sub pathways below

Individual pathways:

Drag a box around points to select pathways of interest

Selected pathways:

Select a row to explore pathway sensitivity below

Differential sensitivity per compound:

Drag a box around points to select compounds of interest

Selected compounds:

Select a row to plot compound/target sensitivity accross cell lines below

Selected compound:

Differential ranking:

Differential sensitivity ranks indicate how selectively sensitive the celltype of interest is relative to the control population (higher rank = more selective). Three primary metrics are considered - the CRISPR effect score, RNAi effect score, and drug sensitivity score (DSS).

Drug sensitivity metrics:

Drug sensitivity scores integrate the dose-response curve into a single metric - (higher score = more sensitive, range 0-100)

Target Dependency:

CRISPR effect scores indicate the effect of gene knock-out on viability - (lower score = more sensitive)

RNAi:

RNAi effect scores indicate the effect of gene knock-down on viability - (lower scores = more sensitive)

Differential gene dependency scores:

Drag a box around points to select genes of interest

Selected genes:

Select a row to plot gene dependency accross cell lines below

Selected gene:

Differential ranking:

Differential sensitivity ranks indicate how selectively dependent the celltype of interest is relative to the control population (higher rank = more selective). Three primary metrics are considered - the CRISPR effect score, RNAi effect score, and drug sensitivity score (DSS).

CRISPR metrics:

CRISPR effect scores indicate the effect of gene knock-out on viability - (more negative = more dependent on gene)

RNAi metrics:

RNAi scores indicate the effect of gene knock-out on viability - (more negative = more dependent on gene)