Arsenic metabolism and reactive oxygen species generation
Altered glycosylation of MUC1 in tumor microenvironment
Interleukin-1 induced activation of NF-kB
Regulation of Wnt / B-catenin signaling by small molecule compounds
Mammary gland development: puberty - stage 2 of 4
TNF-related weak inducer of apoptosis (TWEAK) signaling
Effect of dasatinib on the BCR-ABL signaling pathway
MAPK pathway in congenital thyroid cancer
Hallmark of cancer: sustaining proliferative signaling
Mevalonate arm of cholesterol biosynthesis pathway with inhibitors
Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism
Disorders of bile acid synthesis and biliary transport
Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway
Cholesterol biosynthesis with skeletal dysplasias
Urea cycle and metabolism of amino groups
Trans-sulfuration, one-carbon metabolism and related pathways
Kynurenine pathway and links to cell senescence
Biomarkers for pyrimidine metabolism disorders
TCA cycle (aka Krebs or citric acid cycle)
TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc)
Mitochondrial complex I assembly model OXPHOS system
Pentose phosphate pathway in senescent cells
Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists
Biosynthesis and turnover of 1-deoxy-sphingoid bases
Synthesis of ceramides and 1-deoxyceramides
Metabolism of dichloroethylene by CYP450
Vitamin D-sensitive calcium signaling in depression
Non-genomic actions of 1,25-dihydroxyvitamin D3
Warburg effect modulated by deubiquitinating enzymes and their substrates
PGK1, PKM2, KHKC/KHKA acting as protein kinases
Acetaminophen in analgesia and antipyresis
Pathways into methionine and folate cycles
Disorders of folate metabolism and transport
Octadecanoid formation from linoleic acid
Dengue-2 interactions with complement and coagulation cascades
Eicosanoid metabolism via cyclooxygenases (COX)
Arachidonic acid (AA, ARA) oxylipin metabolism
Female steroid hormones in cardiomyocyte energy metabolism
Eicosanoid metabolism via lipooxygenases (LOX)
Arachidonate epoxygenase / epoxide hydrolase
Eicosanoid metabolism via cytochrome P450 monooxygenases pathway
Primary focal segmental glomerulosclerosis (FSGS)
Cholesterol metabolism with Bloch and Kandutsch-Russell pathways
Prostaglandin and leukotriene metabolism in senescence
Androgen receptor network in prostate cancer
Alternative pathway of fetal androgen synthesis
Male steroid hormones in cardiomyocyte energy metabolism
Tryptophan catabolism leading to NAD+ production
Cell-type dependent selectivity of CCK2R signaling
Leucine, isoleucine and valine metabolism
Vitamin B6-dependent and responsive disorders
Amino acid metabolism pathway excerpt: histidine catabolism extension
Mitochondrial carrier deficiency associated with shuttle disturbances
Mitochondrial fatty acid oxidation disorders
Mitochondrial long chain fatty acid beta-oxidation
Cholesterol biosynthesis pathway in hepatocytes
FGF23 signaling in hypophosphatemic rickets and related disorders
Cardiomyocyte signaling converging on titin
Mevalonate arm of cholesterol biosynthesis pathway
Mitochondrial fatty acid synthesis pathway
Metabolism of sphingolipids in ER and Golgi apparatus
Nanoparticle triggered autophagic cell death
Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine
Amino acid metabolism in triple-negative breast cancer cells
FGFR3 signaling in chondrocyte proliferation and terminal differentiation
Glycosylation and related congenital defects
Regucalcin in proximal tubule epithelial kidney cells
4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression
PI3K-AKT-mTOR signaling and therapeutic opportunities in prostate cancer
Translation inhibitors in chronically activated PDGFRA cells
Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling
Folate-alcohol and cancer pathway hypotheses
Ethanol effects on histone modifications
Transcriptional activation by NRF2 in response to phytochemicals
Ethanol metabolism production of ROS by CYP2E1
Pluripotent stem cell differentiation pathway
Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms
Splicing factor NOVA regulated synaptic proteins
Nucleotide-binding oligomerization domain (NOD) pathway
Statin inhibition of cholesterol production
Fatty acid and lipoprotein transport in hepatocytes
Bile acid synthesis and enterohepatic circulation
Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling
Angiopoietin-like protein 8 regulatory pathway
Cyclin-dependent kinase 4/6 inhibitors in breast cancer
DNA damage response (only ATM dependent)
Apoptosis-related network due to altered Notch3 in ovarian cancer
DNA IR-double strand breaks and cellular response via ATM
Major receptors targeted by epinephrine and norepinephrine
Thyroid hormones production and peripheral downstream signaling effects
Clear cell renal cell carcinoma pathways
Sterol regulatory element-binding proteins (SREBP) signaling
Brain-derived neurotrophic factor (BDNF) signaling
Conversion of angiotensinogen to angiotensin II
Complement-mediated inflammation of pulmonary alveolus in COVID-19 (hypothetical pathway)
SCFA and skeletal muscle substrate metabolism
Glucose metabolism in triple-negative breast cancer cells
Secretion of hydrochloric acid in parietal cells
Metabolic reprogramming in pancreatic cancer
Cell lineage map for neuronal differentiation
Quercetin and Nf-kB / AP-1 induced apoptosis
Roles of ceramides in development of insulin resistance
Fas ligand pathway and stress induction of heat shock proteins
Myometrial relaxation and contraction pathways
Common pathways underlying drug addiction
Hair follicle development: organogenesis - part 2 of 3
MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement
HDAC6 interactions in the central nervous system
Embryonic stem cell pluripotency pathways
Catabolism of skeletal muscle in cachexia
Interactions of natural killer cells in pancreatic cancer
Canonical and non-canonical Notch signaling
Hair follicle development: cytodifferentiation - stage 3 of 3
Endochondral ossification with skeletal dysplasias
TGF-beta receptor signaling in skeletal dysplasias
Type I collagen synthesis in the context of osteogenesis imperfecta
Pathways of nucleic acid metabolism and innate immune sensing
Serotonin receptor 4/6/7 and NR3C signaling
Envelope proteins and their potential roles in EDMD physiopathology
Resolvin E1 and resolvin D1 signaling decrease inflammation
GPR143 in melanocytes and retinal pigment epithelium cells
Thyroid stimulating hormone (TSH) signaling
Methionine metabolism leading to sulfur amino acids and related disorders
Differentiation of white and brown adipocyte
Influence of laminopathies on Wnt signaling
Transcription factor regulation in adipogenesis
Complement system in neuronal development and plasticity
mRNA, protein, and metabolite inducation pathway by cyclosporin A
Chronic hyperglycemia impairment of neuron function
Pathophysiological roles of DUX4 in FSHD1
Tyrosine kinase inhibitors in glioblastoma
Disorders of mitochondrial homeostatis, dynamics, protein import, and quality control
Autophagy in pancreatic ductal adenocarcinoma
Modulators of TCR signaling and T cell activation
exRNA mechanism of action and biogenesis
Neurogenesis regulation in the olfactory epithelium
Physiological and pathological hypertrophy of the heart
Development and heterogeneity of the ILC family
Metapathway biotransformation Phase I and II
Somatroph axis (GH) and its relationship to dietary restriction and aging
TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition
Nanoparticle-mediated activation of receptor signaling
Mammary gland development: embryonic development - stage 1 of 4
Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids
Pathways affected in adenoid cystic carcinoma
Chromosomal and microsatellite instability in colorectal cancer
MET in type 1 papillary renal cell carcinoma
Epithelial to mesenchymal transition in colorectal cancer
Artemisinin inhibition of uveal melanoma
Kisspeptin/kisspeptin receptor system in the ovary
Neural crest cell migration during development
Inhibition of GNAQ-regulated signaling in uveal melanoma
Relationship between inflammation, COX-2 and EGFR
JAK-STAT signaling in the regulation of beta cells
EGFR tyrosine kinase inhibitor resistance
Targeted agents in triple negative breast cancer
Thymic stromal lymphopoietin (TSLP) signaling
T cell receptor and co-stimulatory signaling
Extracellular vesicle-mediated signaling in recipient cells
Follicle stimulating hormone (FSH) signaling
Regulation of apoptosis by parathyroid hormone-related protein
RIOK1 and RIOK2 in EGFR- and PI3K-mediated tumorigenesis
Growth factors and hormones in beta cell proliferation
NRP1-triggered signaling in pancreatic cancer
DYRK1A involvement regarding cell proliferation in brain development
Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells
GLP-1 secretion from intestine to portal vein
NOTCH1 regulation of endothelial cell calcification
Mammalian disorder of sexual development
GLP-1 from intestine and pancreas and role in glucose homeostasis
mir-124 predicted interactions with cell cycle and differentiation
NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence
Photodynamic therapy-induced HIF-1 survival signaling
GNAQ p.R183Q drives capillary malformation
COVID-19 and endothelial cell senescence
Development of ureteric derived collecting system
Interactions between LOXL4 and oxidative stress pathway
mBDNF and proBDNF regulation of GABA neurotransmission
Wnt/Beta-catenin signaling inhibitors in current and past clinical trials
Regulation of sister chromatid separation at the metaphase-anaphase transition
lncRNA in canonical Wnt signaling and colorectal cancer
ncRNAs in Wnt signaling in hepatocellular carcinoma
Disruption of postsynaptic signaling by CNV
Overview of proinflammatory and profibrotic mediators
Insulin signaling in adipocytes (normal condition)
Insulin signaling in adipocytes (diabetic condition)
Photodynamic therapy-induced unfolded protein response
Photodynamic therapy-induced AP-1 survival signaling
Novel intracellular components of RIG-I-like receptor pathway
DDX1 as a regulatory component of the Drosha microprocessor
DNA IR-damage and cellular response via ATR
Targeting YAP in pancreatic ductal adenocarcinoma (PDAC)
Electron transport chain: OXPHOS system in mitochondria
Mammary gland development: pregnancy and lactation - stage 3 of 4
MAP3K1 role in promoting and blocking gonadal determination
BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation
Development of pulmonary dendritic cells and macrophage subsets
Mammary gland development: involution - stage 4 of 4
Pro-survival signaling of neuroprotectin D1
lncRNA-mediated mechanisms of therapeutic resistance
Photodynamic therapy-induced NF-kB survival signaling
Transcriptional regulation of memory B cell differentiation
FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma
Induction of autophagy and toll-like receptor signaling by graphene oxide
Oligodendrocyte specification and differentiation, leading to myelin components for CNS
Extracellular vesicles in the crosstalk of cardiac cells
EDA signaling in hair follicle development
Canonical and non-canonical TGF-B signaling
Bone morphogenic protein signaling and regulation
Nucleotide excision repair in xeroderma pigmentosum
EV release from cardiac cells and their functional effects
let-7 inhibition of ES cell reprogramming
Toll-like receptor signaling related to MyD88
Cells and molecules involved in local acute inflammatory response
MFAP5-mediated ovarian cancer cell motility and invasiveness
GPCRs, class C metabotropic glutamate, pheromone
Initiation of transcription and translation elongation at the HIV-1 LTR
Effect of progerin on genes involved in progeria
Interactions between immune cells and microRNAs in tumor microenvironment
Platelet-mediated interactions with vascular and circulating cells
Immune infiltration in pancreatic cancer
Selective expression of chemokine receptors during T-cell polarization
H19, Rb-E2F1, and CDK-beta-catenin in colorectal cancer
Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer
Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors
Control of immune tolerance by vasoactive intestinal peptide
MAPK and NFkB signaling inhibited by Yersinia YopJ
Vitamin K metabolism and activation of dependent proteins
Multiple epiphyseal dysplasia and pseudoachondroplasia genes
Hepatocyte growth factor receptor signaling
eIF5A regulation in response to inhibition of the nuclear export system
AMPK regulation of mammary milk protein synthesis
Amplification and expansion of oncogenic pathways as metastatic traits
UDP-derived sugars synthesis in fibroblasts
TCA cycle nutrient use and invasiveness of ovarian cancer
Somitogenesis in the context of spondylocostal dysostosis
Intracellular trafficking proteins involved in CMT neuropathy
EPAC1 and PKA reduction of retinal inflammation
Hormonal control of pubertal growth spurt
Evolocumab mechanism to reduce LDL cholesterol
Deregulation of Rab and Rab effector genes in bladder cancer
Catalytic cycle of mammalian flavin-containing monooxygenases (FMOs)
Transcription co-factors SKI and SKIL protein partners
MicroRNA for targeting cancer growth and vascularization in glioblastoma
Suppression of HMGB1-mediated inflammation by THBD
mRNA vaccine activation of dendritic cell and induction of IFN-1
ncRNAs involved in STAT3 signaling in hepatocellular carcinoma
Hallmark of cancer: non-mutational epigenetic reprogramming
Albuterol and budesonide therapy for asthma
Hallmark of cancer: metastasis and epithelial-to-mesenchymal transition
Cell interactions of the pancreatic cancer microenvironment
Clock-controlled autophagy in bone metabolism
Interactome of polycomb repressive complex 2 (PRC2)
MicroRNA network associated with chronic lymphocytic leukemia
Serotonin receptor 2 and ELK-SRF/GATA4 signaling
Tyrosine metabolism and related disorders
Genes related to primary cilium development (based on CRISPR)
Overlap between signal transduction pathways contributing to LMNA laminopathies
Hereditary leiomyomatosis and renal cell carcinoma pathway
Intraflagellar transport proteins binding to dynein