Drug Discovery

Celltype comparison:

Average sensitivity per protein/compound:

Drag a box around points to select compounds of interest

CTD

GDSC

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Selected compounds:

Select a row to plot compound/target sensitivity accross cell lines below
XLS

Cell-line metrics for selected compound/target:

Differential ranking:

Differential sensitivity ranks indicate how selectively sensitive the celltype of interest is relative to the control population (higher rank = more selective). Three primary metrics are considered - the CRISPR effect score, RNAi effect score, and drug sensitivity score (DSS).

Drug sensitivity scores (DSS):

Drug sensitivity scores integrate the dose-response curve into a single metric - (higher score = more sensitive, range 0-100)
XLS
XLS

CRISPR:

CRISPR effect scores indicate the effect of gene knock-out on viability - (lower score = more sensitive)
XLS

RNAi:

RNAi effect scores indicate the effect of gene knock-down on viability - (lower scores = more sensitive)
XLS

Average CRISPR score per gene:

Drag a box around points to select genes of interest
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Selected genes:

Select a row to plot gene dependency accross cell lines below

Average protein expression:

Drag a box around points to select genes of interest
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Selected genes/proteins:

Select a row to plot expression accross cell lines below

Gene hazard ratios:

Drag a box around points to select genes of interest
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Selected genes:

Select a row to plot prognosis effects per subtype/study


HR effects: