Average sensitivity per protein/compound:

Drag a box around points to select compounds of interest

Selected compounds:

Select a row to plot compound/target sensitivity accross cell lines below

Cell-line metrics for selected compound/target:

Differential ranking:

Differential sensitivity ranks indicate how selectively sensitive the celltype of interest is relative to the control population (higher rank = more selective). Three primary metrics are considered - the CRISPR effect score, RNAi effect score, and drug sensitivity score (DSS).

Drug sensitivity scores (DSS):

Drug sensitivity scores integrate the dose-response curve into a single metric - (higher score = more sensitive, range 0-100)

CRISPR:

CRISPR effect scores indicate the effect of gene knock-out on viability - (lower score = more sensitive)

RNAi:

RNAi effect scores indicate the effect of gene knock-down on viability - (lower scores = more sensitive)