Drug Discovery
Celltype comparison:
Average sensitivity per protein/compound:
Drag a box around points to select compounds of interest
Selected compounds:
Select a row to plot compound/target sensitivity accross cell lines below
XLS
Cell-line metrics for selected compound/target:
Differential ranking:
Differential sensitivity ranks indicate how selectively sensitive the celltype of interest is relative to the control population (higher rank = more selective). Three primary metrics are considered - the CRISPR effect score, RNAi effect score, and drug sensitivity score (DSS).
Drug sensitivity scores (DSS):
Drug sensitivity scores integrate the dose-response curve into a single metric - (higher score = more sensitive, range 0-100)
XLS
XLS
CRISPR:
CRISPR effect scores indicate the effect of gene knock-out on viability - (lower score = more sensitive)
XLS
RNAi:
RNAi effect scores indicate the effect of gene knock-down on viability - (lower scores = more sensitive)
XLS
Average CRISPR score per gene:
Drag a box around points to select genes of interest
Selected genes:
Select a row to plot gene dependency accross cell lines below
Average protein expression:
Drag a box around points to select genes of interest
Selected genes/proteins:
Select a row to plot expression accross cell lines below
Gene hazard ratios:
Drag a box around points to select genes of interest
Selected genes:
Select a row to plot prognosis effects per subtype/study
HR effects: