Celltype Vulnerability Explorer

Celltype comparison:

Candidate dependencies in celltype of interest:

Select a row to highlight components below

Pathway-level

Compound-level

Protein-level

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Differential metapathway sensitivity:

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Metapathway info:

Select a row to explore sub pathways below

Individual pathways:

Drag a box around points to select pathways of interest
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Selected pathways:

Select a row to explore pathway sensitivity below
Download pathways summary

Differential sensitivity per compound:

Drag a box around points to select compounds of interest
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Selected compounds:

Select a row to plot compound/target sensitivity accross cell lines below
Download compounds summary

Selected compound:

Differential ranking:

Differential sensitivity ranks indicate how selectively sensitive the celltype of interest is relative to the control population (higher rank = more selective). Three primary metrics are considered - the CRISPR effect score, RNAi effect score, and drug sensitivity score (DSS).

Drug sensitivity metrics:

Drug sensitivity scores integrate the dose-response curve into a single metric - (higher score = more sensitive, range 0-100)
Download compound metrics

Target Dependency:

CRISPR effect scores indicate the effect of gene knock-out on viability - (lower score = more sensitive)

RNAi:

RNAi effect scores indicate the effect of gene knock-down on viability - (lower scores = more sensitive)
Download dependency metrics

Differential gene dependency scores:

Drag a box around points to select genes of interest

CRISPR

RNAi

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Selected genes:

Select a row to plot gene dependency accross cell lines below
Download dependency summary

Selected gene:

Differential ranking:

Differential sensitivity ranks indicate how selectively dependent the celltype of interest is relative to the control population (higher rank = more selective). Three primary metrics are considered - the CRISPR effect score, RNAi effect score, and drug sensitivity score (DSS).


CRISPR metrics:

CRISPR effect scores indicate the effect of gene knock-out on viability - (more negative = more dependent on gene)


RNAi metrics:

RNAi scores indicate the effect of gene knock-out on viability - (more negative = more dependent on gene)